Beauty Bioscience RetinoSyn-45 Titration Therapy Phase 1 2 3 BeautyBio R45 The Reversal is a 3-phase, 45-day intensive nighttime retinol treatment used twice yearly to boost skin rejuvenation. Apply one pump of Side A (retinol) and one pump of Side B (peptide formula) mixed together onto clean, dry skin before moisturizer. Increase concentration every two weeks (Phases 1-3). BeautyBio BeautyBio +3 Step-by-Step Usage Instructions When to Use: Exclusively at night. Use it for 2 weeks per phase, for a total of 6 weeks (45 days). Preparation: Cleanse your face and pat it completely dry. A dry face is crucial for reducing irritation. Application: Pump one dose from side A and one dose from side B. Mix them together and apply to the face, neck, and décolleté. Phase Advancement: Start with Phase 1. When the bottles are empty (approx. 2 weeks), move to Phase 2, then Phase 3. Routine Adjustments: During these 45 days, pause other intensive treatments or serums.